Regulation of Circadian Rhythm Through SCN and non-SCN Factors
نویسنده
چکیده
of Dissertation Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Biology in the Graduate School of Arts and Sciences of Northeastern University, December 2010 Northeastern University Boston, MA December 2010
منابع مشابه
Circadian Rhythm Disturbances in Mood Disorders: Insights into the Role of the Suprachiasmatic Nucleus
Circadian rhythm disturbances are a common symptom among individuals with mood disorders. The suprachiasmatic nucleus (SCN), in the ventral part of the anterior hypothalamus, orchestrates physiological and behavioral circadian rhythms. The SCN consists of self-sustaining oscillators and receives photic and nonphotic cues, which entrain the SCN to the external environment. In turn, through synap...
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In mammals, the principal circadian pacemaker driving daily physiology and behavioral rhythms is located in the suprachiasmatic nucleus (SCN) in the anterior hypothalamus. The neural output of SCN is essential for the circadian regulation of behavioral activity. Although remarkable progress has been made in revealing the molecular basis of circadian rhythm generation within the SCN, the output ...
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The mammalian circadian pacemaker in the suprachiasmatic nuclei (SCN) controls daily rhythms of behavior and physiology. Lesions of the SCN cause arrhythmicity of locomotor activity, and transplants of fetal SCN tissue restore rhythmic behavior that is consistent with the periodicity of the donor's genotype, suggesting that the SCN determines the period of the circadian behavioral rhythm. While...
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Cocaine abuse is highly disruptive to circadian physiological and behavioral rhythms. The present study was undertaken to determine if such effects are manifest through actions on critical photic and non-photic regulatory pathways in the master circadian clock of the mouse suprachiasmatic nucleus (SCN). Impairment of SCN photic signaling by systemic (i.p.) cocaine injection was evidenced by str...
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